Recommended by Dr. Greg Eckel

Nitric Oxide Levels Jump 200% Higher In Just 20 Minutes

Boost your energy, sharpen memory, increase stamina, support heart health, and help lower blood pressure with this Nobel Prize-winning discovery.

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The Science Behind CircO2

NOBEL PRIZE WINNING

Based on the Nobel Prize-winning discovery of Nitric Oxide as a signaling molecule for cardiovascular health.

20-MINUTE ACTIVATION

In clinical testing, CircO2 raised nitric oxide levels by 200% in just 20 minutes after taking a single lozenge.

LOZENGE DELIVERY

Dissolves in the mouth to activate essential bacteria, bypassing the stomach for maximum nitric oxide production.

RISK FREE

Try it completely risk-free with our 90-day "Down to the Last Lozenge" money-back guarantee.

What Is CircO2 Nitric Oxide Booster?

CircO2 Nitric Oxide Booster supplement bottle

CircO2 is a clinically studied nitric oxide booster developed by Advanced Bionutritionals and formulated by Dr. Greg Eckel, a renowned naturopathic physician. Unlike traditional nitric oxide supplements that come in capsule or powder form, CircO2 is a fast-dissolving lozenge that you place on your tongue.

This unique delivery method is based on an MIT breakthrough discovery that found nitric oxide production actually begins in the mouth — not in the stomach. When you let the CircO2 lozenge dissolve on your tongue, it activates the beneficial bacteria that are essential for converting nitrates into nitric oxide. This bypasses the stomach acid that destroys up to 75% of the active ingredients in regular supplements.

In clinical testing, CircO2 was shown to increase nitric oxide levels by 200% in just 20 minutes. It contains a synergistic blend of Beet Root Powder, L-Citrulline, Hawthorn Berry Extract, Vitamin B12, and Vitamin C — all working together to support healthy blood flow, energy production, cognitive function, and cardiovascular health.

Each box of CircO2 contains 30 lozenges (a one-month supply). The lozenges have a pleasant berry flavor and require no water — simply place one on your tongue daily and feel the difference. CircO2 is manufactured in the USA in a GMP-certified facility and comes with a 90-day money-back guarantee.

Why You Need Nitric Oxide

Nitric Oxide (NO) is often called the "youth molecule" — a tiny but powerful gas your body produces naturally. It was the subject of the 1998 Nobel Prize in Physiology or Medicine, when three American scientists (Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad) discovered its role as a critical signaling molecule in the cardiovascular system.

Nitric oxide is responsible for keeping your blood vessels relaxed and open, allowing oxygen-rich blood to flow freely to every organ — your heart, brain, lungs, muscles, and joints. Without adequate nitric oxide, blood vessels constrict, oxygen delivery drops, and your body begins to struggle.

The problem? Nitric oxide production declines dramatically with age. Research published in leading medical journals shows that by age 40, your body produces about 50% less nitric oxide than it did in your 20s. By age 70, levels have plummeted by 75%. And by 80, they can be down by as much as 85%.

This dramatic decline is the hidden cause behind many age-related concerns:

Chronic fatigue and low energy
Rising blood pressure concerns
Memory lapses and brain fog
Poor circulation and cold extremities
Restless sleep and slow recovery
Reduced stamina and endurance

When nitric oxide plummets, you don't just feel older — your body literally starves for oxygen and nutrients. Every cell, tissue, and organ suffers. The good news? CircO2 is specifically designed to restore nitric oxide levels quickly and effectively, helping you reclaim the energy and vitality you thought was gone forever.

Restore Nitric Oxide Now

The MIT Breakthrough That Changes Everything

MIT scientists discovered that nitric oxide production starts in your mouth. Conventional pills fail because stomach acid destroys the ingredients. CircO2 is different.

Starts In Your Mouth

Beneficial bacteria on your tongue convert nitrates into nitric oxide. This is the first and most crucial step in nitric oxide production.

Fast-Dissolving Lozenge

CircO2 lozenges dissolve in your mouth, bypassing the stomach acid that destroys 75% of L-arginine in standard supplements.

Beet Root Powder

Rich in natural nitrates, beet root helps open blood vessels, improve oxygen flow, and supercharge stamina. A favorite of Olympic athletes. Studies show beet root can increase exercise endurance by up to 16% and significantly lower systolic blood pressure. The nitrates in beet root are converted by oral bacteria into nitric oxide, making the lozenge delivery system ideal.

Hawthorn Berry Extract

Used for centuries in traditional European medicine for heart health, Hawthorn Berry is rich in flavonoids and antioxidants. It enhances nitric oxide bioavailability, strengthens blood vessel walls, and supports healthy blood pressure. Clinical research confirms its ability to improve coronary artery blood flow and reduce symptoms of mild heart failure.

L-Citrulline

L-Citrulline is an amino acid that converts to L-arginine in the kidneys, which then produces nitric oxide. Research shows L-Citrulline is more effective at raising nitric oxide levels than taking L-arginine directly, because it bypasses first-pass metabolism in the liver. It's especially beneficial for those over 45, supporting circulation, memory, physical stamina, and healthy blood pressure.

Vitamin B12 (Methylcobalamin)

Vitamin B12 is essential for energy production, nerve health, and red blood cell formation. Up to 40% of adults over 60 are deficient in B12, leading to fatigue and cognitive decline. CircO2 uses methylcobalamin, the most bioavailable form, to ensure maximum absorption through the oral mucosa.

Vitamin C (Ascorbic Acid)

Vitamin C acts as a powerful catalyst for nitric oxide production and protects it from oxidative damage. It helps stabilize the nitric oxide molecule so it lasts longer in your bloodstream, extending the benefits of each lozenge. Vitamin C also supports immune function and collagen production for healthy blood vessels.

In Summary

CircO2 uses a scientifically advanced delivery system to ensure your body actually gets the nitric oxide it needs. By simply letting a lozenge dissolve in your mouth, you can boost your nitric oxide levels by 200% in just 20 minutes. It's the most effective way to restore the energy and vitality of your youth.

Restore Your Energy Today

Why Boost Nitric Oxide?

Experience the life-changing power of healthy circulation.

Renewed Energy & Stamina

Renewed energy and stamina to stay active, travel, or pursue passions without afternoon fatigue.

Sharper Thinking & Recall

Remember names, where you put things, and maintain your mental edge in conversations.

Healthier Blood Pressure

Support healthier blood pressure readings that will impress your doctor.

Enhanced Mobility & Comfort

Experience better joint comfort as your joints receive more oxygen and nutrients.

More Restful Sleep

Enjoy deeper sleep and wake up feeling refreshed, not groggy.

Youthful Vitality

A sense of youth and vitality as your brain and body receive optimal oxygen and nutrients.

Yes! I Want These Benefits

Who Should Use CircO2?

CircO2 Is Ideal For You If:

  • You are over 40 years old and notice declining energy levels throughout the day
  • You want to support healthy blood pressure naturally without harsh chemicals
  • You experience memory lapses, brain fog, or difficulty concentrating
  • You feel tired and sluggish even after a full night's sleep
  • You want to improve cardiovascular health and circulation
  • You are looking for a natural nitric oxide supplement backed by clinical research
  • You have cold hands and feet or signs of poor circulation
  • You want to maintain an active lifestyle with more stamina and endurance

Consult Your Doctor First If:

  • You are pregnant or nursing
  • You are currently taking blood pressure medication or blood thinners
  • You have a scheduled surgery within the next 2 weeks
  • You have a known medical condition requiring ongoing treatment
  • You are under 18 years of age

CircO2 is formulated with natural ingredients and is generally well-tolerated. However, it's always wise to consult with your healthcare provider before starting any new supplement, especially if you have existing health conditions or are on medication.

CircO2 Side Effects & Safety Information

Safety is a top priority for Advanced Bionutritionals. CircO2 is manufactured in the United States in a GMP-certified facility (Good Manufacturing Practices) that follows strict quality control standards. Each batch is tested for purity and potency to ensure you receive a safe and effective product.

Are There Any Side Effects?

CircO2 is made from natural, well-researched ingredients and is generally well-tolerated by most adults. Based on customer feedback and the clinical profile of its ingredients, side effects are rare. However, as with any dietary supplement, some individuals may experience:

What Makes CircO2 Safe

  • 100% natural ingredients
  • Manufactured in GMP-certified USA facility
  • No artificial stimulants or caffeine
  • No habit-forming ingredients
  • Formulated by licensed naturopathic physician
  • Backed by published scientific research

Rare, Mild Reactions

  • Mild digestive discomfort (very rare)
  • Slight headache during first few days
  • Temporary flushing (sign of increased blood flow)
  • Mild dizziness if taken on empty stomach

These effects are uncommon and typically resolve on their own within 1-2 days as your body adjusts.

Important: CircO2 is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. If you are currently taking prescription medications, particularly blood pressure medication or blood thinners, consult your healthcare provider before use. CircO2 comes with a 90-day money-back guarantee, so you can try it completely risk-free.

Meet The Doctor Behind CircO2

Dr. Greg Eckel

Naturopathic Physician

Dr. Greg Eckel, ND, LAc is a licensed naturopathic physician and acupuncturist with over two decades of clinical experience. He is the formulator behind CircO2 and a trusted voice in integrative medicine. Dr. Eckel has dedicated his career to finding natural, science-backed solutions that help people age gracefully and maintain their vitality.

Dr. Eckel's work with Advanced Bionutritionals focuses on translating cutting-edge research into practical health solutions. His approach combines the latest discoveries in nitric oxide science with time-tested natural ingredients. He was inspired to create CircO2 after reviewing the MIT research showing that nitric oxide production begins in the mouth, not the stomach \u2014 making traditional capsule-based supplements far less effective.

As a practitioner at Nature Cures Clinic in Portland, Oregon, Dr. Eckel has helped thousands of patients improve their cardiovascular health, energy levels, and cognitive function through evidence-based natural therapies. His philosophy is simple: "Give the body what it needs, in the form it can actually use, and remarkable things happen."

Naturopathic Doctor (ND) Licensed Acupuncturist 20+ Years Experience Advanced Bionutritionals

Success Stories

Randy W.

Verified Customer
"This supplement works very good. I could feel the results within a couple days. So much easier to get a deeper breath now."

Linda S., Sanford, NC

Verified Customer
"CircO2 is my favorite supplement for my blood pressure. I used this supplement for many years now... it keeps my blood pressure in normal range."

Paul W., Humble, TX

Verified Customer
"I take this every other day and can honestly say they are great for helping me regulate my BP."
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Frequently Asked Questions About CircO2

CircO2 is a fast-dissolving lozenge that boosts your body's nitric oxide levels. It works by dissolving on your tongue, where beneficial oral bacteria convert the natural nitrates in the formula into nitric oxide. This bypasses the stomach acid that destroys most traditional supplements. In clinical testing, CircO2 raised nitric oxide levels by 200% in just 20 minutes.

Yes. CircO2 is made with 100% natural ingredients and is manufactured in a GMP-certified facility in the USA. It contains no artificial stimulants, caffeine, or habit-forming substances. However, if you have a medical condition or are taking medication (especially blood pressure drugs or blood thinners), please consult your doctor first.

Many people feel a noticeable difference in energy within 20 minutes of taking their first lozenge. Nitric oxide levels begin to rise as soon as the lozenge starts dissolving on your tongue. For long-term benefits such as blood pressure support, improved memory, and better sleep, we recommend consistent daily use over 30-90 days.

CircO2 contains five key active ingredients: Beet Root Powder (rich in natural nitrates), L-Citrulline (an amino acid that converts to nitric oxide), Hawthorn Berry Extract (supports cardiovascular health), Vitamin B12 as Methylcobalamin (for energy and nerve health), and Vitamin C (catalyzes nitric oxide production). All ingredients are natural and clinically studied.

The recommended dose is one lozenge per day. Simply place it on your tongue and let it dissolve completely. Do not chew or swallow it whole. Some people take a second lozenge later in the day for an extra energy boost, but one per day is sufficient for most people.

MIT researchers discovered that nitric oxide production begins in the mouth with the help of beneficial bacteria on your tongue. Traditional capsules and powders must pass through stomach acid, which destroys up to 75% of the active ingredients. CircO2's lozenge delivery system ensures the ingredients are absorbed directly through the oral mucosa for maximum effectiveness.

Even if you have good energy levels, nitric oxide is essential for far more than just energy. It supports healthy blood pressure, sharp memory, cardiovascular health, better sleep, and overall vitality. Nitric oxide levels naturally decline with age regardless of how you feel, so replenishing them is a proactive step for long-term health.

CircO2 comes with a full 90-day "Down to the Last Lozenge" money-back guarantee. If you are not completely satisfied with your results, you can return the product (even empty boxes) within 90 days for a full refund, no questions asked. Contact Advanced Bionutritionals customer support at feedback@AdvancedBionutritionals.com.

CircO2 is made with natural ingredients and is generally safe for most adults. However, if you are currently taking blood pressure medication, blood thinners, or any other prescription drugs, we recommend consulting your healthcare provider before adding CircO2 to your routine.

CircO2 is manufactured in the United States in a GMP-certified (Good Manufacturing Practices) facility. Every batch undergoes rigorous testing for purity, potency, and safety. The formula was developed by Dr. Greg Eckel and is produced by Advanced Bionutritionals, a trusted name in premium quality health supplements.

CircO2 is available in three package options: 1 box (30 lozenges, one-month supply) for $49.95, 3 boxes for $134.85 ($44.95 per box with free shipping), or the best value 6 boxes for $249.00 ($41.50 per box with free shipping). All purchases are covered by the 90-day money-back guarantee.

CircO2 lozenges have a pleasant berry flavor. They dissolve smoothly on your tongue without any unpleasant aftertaste. Many customers say they actually look forward to taking their daily lozenge.

Have more questions? Our support team is ready to help!

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How To Use CircO2

1

Take One Lozenge

Take one CircO2 lozenge daily. You can take it at any time of the day that is convenient for you.

2

Let It Dissolve

Place the lozenge on your tongue and let it dissolve completely. Do not chew or swallow it whole.

3

Feel The Boost

As it dissolves, your nitric oxide levels will rise. You should feel an energy lift within about 20 minutes.

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90-Day Money-Back Guarantee

1.
Risk-Free 90-Day Refund: CircO2 offers a full 90-day money-back promise. If you don't feel the energy boost, obtain a full refund.
2.
Scientifically Verified: Backed by Nobel Prize winning research and developed by Dr. Greg Eckel.
3.
Empty Box Guarantee: Return the empty boxes if you are not satisfied, and we will still refund you.

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CircO2 90-Day Money-Back Guarantee

Refund Policy:

We offer a 90-Day Money-Back Guarantee. If you’re not satisfied with your results in energy and vitality, you’re eligible for a full refund within 90 DAYS.

To request a refund or get assistance:

feedback@AdvancedBionutritionals.com
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